PRODH Polymorphisms, Cortical Volumes and Thickness in Schizophrenia
نویسندگان
چکیده
منابع مشابه
PRODH Polymorphisms, Cortical Volumes and Thickness in Schizophrenia
Schizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes. To further evaluate the roles of the associated variants in the disorder, we have conducted magnetic resonance imaging (MRI) sc...
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BACKGROUND Schizophrenia and bipolar disorder are severe psychiatric diseases with overlapping symptomatology. Widespread brain morphologic abnormalities, including cortical thinning and subcortical volume reductions, have been demonstrated in schizophrenia but it is unclear whether similar abnormalities are present in bipolar disorder. The purpose of this study was to compare cortical thicknes...
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The current study provides a complete MRI analysis of thickness throughout the cerebral cortical mantle in patients with schizophrenia (SZ) and rigorously screened and matched unaffected relatives and controls and an assessment of its relation to psychopathology and subjective cognitive function. We analyzed 3D-anatomical magnetic resonance imaging data sets, obtained at 3 Tesla, from three dif...
متن کاملReduced cortical thickness in first episode schizophrenia.
OBJECTIVE Previous morphometric studies are suggesting altered cortical thickness mainly in prefronto-temporal regions in first episode schizophrenia. In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia. METHODS A group of ...
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Nowadays the prevalence of epilepsy is estimated to be around 1% of the population where up to 40% of the patients continue to have seizures despite optimal drug treatment [1]. In patients with drug refractory epilepsy, approximately one-half suffer from localized malformation of cortical development known as focal cortical dysplasia (FCD). There, the epilepsy surgery can yield a high chance of...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0087686